Pill guide
GLP-1 pills for weight loss: Wegovy pill vs Foundayo
Two GLP-1 pills are now FDA-approved for weight management. Here is how they differ in ingredient, label, evidence and price, from official sources.
Programs that list the Wegovy pill and Foundayo
- Ro$39 first month, then $149/mo membership (from $74/mo prepaid yearly). Lists Wegovy pill & pen, Zepbound, Foundayo.
- WeightWatchers Med+$25 first month, then $74–$84/mo on a 12- or 6-month plan. Lists Wegovy pill & pen, Zepbound, Foundayo.
- Amazon One Medical$39 message or $59 video visit, no membership required. Wegovy pill & injection, Zepbound, Foundayo.
- Hims & Hers$39 first month, then $149/mo; medicine from $149/mo. Cash-pay Wegovy pill & pen, Zepbound, Foundayo.
Not a ranking; facts from official pages, checked 9 November 2026. Buttons open the program’s site; we may earn a commission from some links. Disclosure.
Educational, not medical advice. Only a clinician licensed in your state can decide whether a prescription medicine is right for you. We do not give dosing instructions. In an emergency, call 911. Medical disclaimer.
Disclosure: buttons go to official websites. If we add partner links later, a signup may earn us a commission at no cost to you. Advertising disclosure. We do not promote compounded or “research use only” GLP-1 products.
Short answer: the Wegovy pill (oral semaglutide) and Foundayo (orforglipron) are the two FDA-approved GLP-1 pills for weight management. Both start at $149 a month self-pay. Foundayo has no food or water timing rules; the Wegovy pill has a cardiovascular indication.
Wegovy pill vs Foundayo
| Wegovy pill | Foundayo | |
|---|---|---|
| Maker | Novo Nordisk | Eli Lilly |
| Ingredient | semaglutide (oral), the same ingredient as Wegovy injection | orforglipron, a small-molecule (non-peptide) GLP-1 receptor agonist Lilly: FDA approves Foundayo, 1 Apr 2026 ↗ |
| FDA approval | 22 December 2025 | 1 April 2026 |
| Approved for | weight reduction; cardiovascular risk reduction in adults with established cardiovascular disease and obesity or overweight | adults with obesity, or overweight with at least one weight-related condition |
| How it is taken | once daily, with timing rules around food and water set out in the label | once daily, with or without food per the label; Lilly says it can be taken any time of day without food or water restrictions |
| Key trial | OASIS 4 (64 weeks, 307 adults): 13.6% vs 2.4% with placebo; 16.6% vs 2.7% among those who stayed on treatment Novo Nordisk: Wegovy pill FDA approval and OASIS 4 results ↗ | two 72-week placebo-controlled trials supported approval FDA: Foundayo approval, 1 Apr 2026 ↗ |
| Self-pay price per month | $149 (1.5 mg), $199 (4 mg), $299 (9 mg and 25 mg) Wegovy cost & coverage (Novo Nordisk) ↗ | from $149 (0.8 mg) to $349 (14.5 and 17.2 mg; $299 with refills within 45 days) Foundayo coverage & savings (Lilly) ↗ |
| With commercial insurance | as little as $25 a month if covered (maximum savings $100 a month) Wegovy cost & coverage (Novo Nordisk) ↗ | as little as $25 with the savings card if covered Lilly: Foundayo cost information ↗ |
Pill or injection: questions to discuss
- Would a daily tablet or a weekly injection fit your routine better?
- Do the Wegovy pill's timing rules fit your mornings and other medicines?
- Do you have a condition, such as established cardiovascular disease, where an approved indication matters?
- Does your insurance cover one form and not the other?
Compare with injections in Zepbound vs Wegovy and which GLP-1 is best.
Not the same as Rybelsus or Ozempic
Rybelsus (oral semaglutide) and Ozempic are approved for type 2 diabetes. Using a diabetes brand for weight loss is off-label and often treated differently by insurers.
Online programs that list the pills
From official program pages checked 9 November 2026: Wegovy pill: Ro, WeightWatchers Med+, PlushCare, Hims & Hers, Amazon One Medical, Sesame, Knownwell. Foundayo: Ro, WeightWatchers Med+, PlushCare, Hims & Hers, Amazon One Medical, Knownwell. Compare program fees.
Related guides
- GLP-1 cost in 2026: Zepbound, Wegovy, Wegovy pill and Foundayo prices
- Cheapest FDA-approved GLP-1 without insurance
- Which GLP-1 is best for weight loss?
- Zepbound vs Wegovy: cost, trial results and differences
- FDA-approved GLP-1 medicines in the US
Sources
- Novo Nordisk: Wegovy pill FDA approval and OASIS 4 results ↗ — checked 9 November 2026.
- FDA: Foundayo approval, 1 Apr 2026 ↗ — checked 9 November 2026.
- Lilly: FDA approves Foundayo, 1 Apr 2026 ↗ — checked 9 November 2026.
- Foundayo prescribing information (Lilly, PDF) ↗ — checked 9 November 2026.
- Wegovy cost & coverage (Novo Nordisk) ↗ — checked 9 November 2026.
- Foundayo coverage & savings (Lilly) ↗ — checked 9 November 2026.
- Lilly: Foundayo cost information ↗ — checked 9 November 2026.
- Drugs@FDA: current product labeling ↗ — checked 9 November 2026.
Frequently asked questions
Is there a GLP-1 pill for weight loss?
Yes. Two are FDA-approved for weight management: the Wegovy pill (oral semaglutide, approved 22 December 2025) and Foundayo (orforglipron, approved 1 April 2026). Rybelsus is an oral semaglutide approved only for type 2 diabetes.
What is the difference between the Wegovy pill and Foundayo?
The Wegovy pill contains semaglutide and has timing rules around food and water set out in its label. Foundayo contains orforglipron, a non-peptide molecule, and Lilly says it can be taken any time of day without food or water restrictions. The Wegovy pill also has a cardiovascular risk-reduction indication.
How much do GLP-1 pills cost without insurance?
As of 9 November 2026, both start at $149 a month for the lowest strength. The Wegovy pill tops out at $299 and Foundayo at $349, or $299 with refills within 45 days.
Are GLP-1 pills as effective as injections?
No published trial compares the pills directly with the injections. In OASIS 4, people on the Wegovy pill lost 13.6% of body weight on average versus 2.4% with placebo over 64 weeks. Effectiveness for an individual varies.
Where can I get the Wegovy pill or Foundayo online?
Among the services we list, Ro, WeightWatchers Med+, PlushCare, Hims & Hers, Amazon One Medical and Knownwell list both, and Sesame mentions the Wegovy pill. A licensed clinician must prescribe it.